Amino acid sequence of the encephalitogenic basic protein from human myelin
نویسندگان
چکیده
منابع مشابه
N-terminal sequence of an encephalitogenic protein form human myelin.
Experimental allergic encephalomyelitis is produced by injection of a basic protein from centralnervous tissue mixed with Freund's complete adjuvant into guinea pigs (Kies, 1965; Carnegie, Bencina & Lamoureux, 1967). The encephalitogenic basic protein is a component of myelin (Laatsch, Kies, Gordon & Alvord, 1962; Roboz-Einstein, Csejtey & Davis, 1965; Eng, Chao, Gerstl, Pratt & Tavaststjerna, ...
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In order to resolve the uncertainties about the primary structure of human myelin basic protein at residues 45-89, the sequence of this peptide and its tryptic fragments were reinvestigated by fast atom bombardment mass spectrometry. The sequence at positions 77-78 was found to be His-Gly and the sequence at positions 83-84 was shown to be Glu-Asn. The Ser at position 56 was not phosphorylated,...
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The amino acid sequences of the encephalitogenic basic protein, A1, from bovine and human myelin are similar, differing by only 11 residues. The sequence reveals that while basic residues are spread randomly over most of the polypeptide chain, several regions (8-10 residues) exist that are nonpolar in character. The bovine protein has 170 residues with molecular weight 18,400. The human protein...
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The antigenic determinants of bovine myelin encephalitogenic protein were investigated by quantitative complement fixation and hapten inhibition using rabbit anti-monkey protein and anti-bovine protein and purified and characterized fragments of bovine protein. The two regions of bovine encephalitogenic protein containing determinants were sequences 1 to 43 and 90 to 170. One rabbit antiserum r...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1971
ISSN: 0306-3283
DOI: 10.1042/bj1230057